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Generation and characterization of functional cardiomyocytes from rhesus monkey embryonic stem cells.
Stem cells therapy for Heart Disease
Heart disease including coronary artery disease is the most common in the developed nations. Present therapies for treating heart disease are insufficient, and cell based methods of treating, may result a noticeably enhanced treatment choices. Because an adult heart muscles do not undergo mitosis anymore, damage of heart muscles caused by ischemic loss of Cardiomycytes is permanent, schwanke,et al (2006). For many years scientists have been searching for an alternative adequate treatment for cardiac disease. As a result a lot of researches and clinical trials approach regarding Stem Cells Usage for treating Heart disease.
What are stem cells?
Stem cells are Stem cells are relatively undifferentiated cells which slowly divide in many tissues (most prominently in the bone marrow, epidermis and gut lining) throughout an individual’s lifetime, producing a continuous supply of new stem cells and a new population of cells that replaces the specialized dying cells in that tissue. http://medsci.indiana.edu/histo/docs/apo1.htm
Although treating heart disease with stem cells is still on trail and it’s not a promising step to totally cure cardiac disease, it’s a good step towards higher aspects of giving hope to some people with heart failure. A study by Schwanke et al. showed that functional heart muscles can be generated from a monkeys embryonic stem cell also they were able to generate endodermal and mesoderm cells that differentiated to cardiomyocytes. An 18% of embryonic stem cells had spontaneously contracting embryonic bodies.
Semi quantitative reverse transcription polymerase chain reaction analysis showed genes that were typical to endoderm, mesoderm, cardiac mesoderm and cardiomyocytes including most of the proteins and growth factors. Also...
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